Congratulations to Pauline for her review “Three decades of unveiling the complex chemistry of C-nitroso species with computational chemistry” just published in Organic Chemistry Frontiers!
A good opportunity to revisit or discover the versatile reactivity of nitroso derivatives and their applications to various synthetic targets, this review provides a pragmatic illustration of the synergistic combination of computational and synthetic organic chemistry. The approach not only supports the rationalization of mechanisms and selectivities, but also bolsters the design of “smarter” reagents and more efficient syntheses. We hope the review will offer a roadmap for predicting and harnessing the multifaceted chemistry of C-nitroso compounds.